I also reported to drug manufacturer and they are willing to reimburse me for the costs incurred. Today shes been panting. the vet suggested it because she has hookworm..This morning she was shaking and no appetite..After reading all these comments I am scared to death for her. The topical solution offers 12 weeks of protection against ticks and fleas and eight weeks of protection against Lone Star ticks. They want $5k to do a spinal tap and MRI. The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. They gave him a strong shot of prednisone that was good for 2 days . So sorry to hear, and good for you in recognizing the problem! Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. The issues started within 24 hours of the dose and continue. He first started with seizures and losing weight in June after giving him Simparica. This is just another reason to follow your vet's recommendations for annual physical exams and tests. Gave Simparica to my dog yesterday. They would clear up after a round of antibiotics but would return the next month. The FDA considers this level to be "very rare". The vet recognized immediately that she was in severe neurogical distress. Was hospitalized for 2 1/2 days. Im throwing away the remaining 5 pills and going back to a topical medicine. Im so angry at these drug companies and vets for selling this crap. Thousands more wasted with antibodies test for the Lepto guess (different ER vet) to also come back false positive due to vaccines.. my poor baby already had a rough life being abandoned. Any other alternatives that are not harmful? He seems dehydrated. I am trying to remain confident that my poor girl will recover. Hopefully yours will be lucky and return to normal. Doctor prescribed the salyien with some injunction but all are in vain..my labrador has same issues till datemy vet.not says anything about the side effect of the Simparica..i m now helpless..pls help me what should I do.. please help me to rid over itpls pls ..guide me. But now I'm almost convinced that they could have been seizures, and I just pray that they weren't, and pray that he doesn't have to experience anymore troubles. They said , he has a Autoimmune Hemolytic anemia . She's finally resting at home, but still not able to walk, run, eat, etc. She also started with ear infections. That night he seemed a little uncomfortable, unable to sleep, and I didnt think anything of it. They kindly asked that we schedule an immediate check and diagnostic testing at our local vet. I will never give this again! My 5 year old Bichon Frises, Ivy, was on NextGard for years. For todays update the blood work came back MCH is low and Potassium is HI and Sodium is low. The door is open , its where he prefers to sleep on a doggie bed . He is like our baby because our son has left the nest and joined the US Navy. We took him to a emergency Vet Hospital that pin pointed Simparica Trio as the main facture that triggered his controlled seizure episodes in having constant all day tremors & seizures hurting him to the point of making the decision to put him down or have him continue with the pain until it killed him. I had placed an order with Pet Meds for the prescription before I saw any of these side effects.I will be returning this medication and order Heartgard and not sure what we will do for flea and ticks, since he turns his nos Simparica Trio, e to the Nexgard and we really dont feel safe with our Grandson around the topical or collarAny suggestions? She definitely is not herself and behaving strangely. It went away. My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. I need to tell my vet to switch! He was lethargic & laying in his crate alot . His blood work came back normal but the vet called me to ask if his simparica somehow coincided with time of the seizures. The king cavalier bichon mix seems to be ok just not eating much if at all. I have been giving my lab puppy (6 months old now) Simparica Trio since October. I am SO angry with my vet and so mad at myself for not researching first. Use a collar or topical if you need to. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. Copyright 2023 Meredith Corporation. Then suddenly dog has diarrhea and it lasted for several days. Tasty, liver-flavored chewable tablet is easy to administer. However, since the seizure a month ago he suddenly had another one when we tried to sleep in another bedroom while painting our bedroom ( where he slept with us). Skin issues. Your veterinarian is the best source of information and will help you choose the right product for your dog and your budget. She seems to be feeling better but still very concerned of why these levels are still up. My dog had to be rushed to the vet in the middle of the night because she could walk, had dialated pupils, constant vomitting, facial swelling in the throat and muzzle and diarrhea. He is 80% its been 27 days since 2nd dose of Simparico.hoping we turned the corner! Also I read on Dr Mercola site that heartworms is in the dogs blood not the digestive track and garlic won't work. Simparica is available by prescription only, so discuss any history your dog has of seizure disorders with your veterinarian when determining the best flea and tick treatment for your pet. My dog has been vomiting with diarrhea plus he has bumps all over his body from one dose of simparica trio. Simparica Trio is intended for dogs and puppies weighing more than 2.8 pounds and older than 8 weeks of age. I'm more concerned about fleas and heartworms and Trifexis is just fine for that. I wish I would have researched this before giving it to my puppy who is only 10 weeks, he has the same symptoms . Thanks! Like many of you, I was unsure about the cause. Decreased conscious proprioception. Was not too excited about it, and I really should've declined it. I have a person that bought a husky puppy from me March 6 @ 6 weeks old. Hi Charlene, can you elaborate on agitated swallowing? All three drugs are pesticides that work by attacking the nervous system of the fleas and ticks, causing death. Product Details: Simparica Trio Chewables for dogs. For the first time in 12 years my dog has 6-7 large kidney stones which will require surgery. Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. Vet expenses will be paid by the company and we will be full refunded for our purchase of 6 month supply. I am taking them both off Simparica. The vet has reported it (at least she too thinks it came from the drug) and a chiropractor checked her for the possiblility of slipped disc etc and said it's not that. before i even gave to my dog small doxie i asked the vet about it and they assured me it was safe since she was and i say was a healthy dog. So I started searching and came across this blog and my heart just sank. Your veterinarian may recommend a heartworm test if you are using Simparica Trio. This junk needs to be pulled from the market. Will it get worse Will he get better? I notified my vet and Zoetis, the company that makes this drug. She couldnt walk straight anymore and stopped eating. My vet never informed me of any issues with this medication and I'm kicking myself hard now after reading all of these horrible experiences with everyone's fur companions. At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. Isoxazoline products have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures in some dogs and cats; Although most dogs and cats havent had neurologic adverse reactions, seizures may occur in animals without a prior history; Many products are available for prevention and control of flea and tick infestations. They have become so bad that she cries and whimpers any time she is laying down. Sunday, he was lethargic and refused to eat. Two days later, she is doing better, but not 100% yet. They were ok on that but the vet office is no longer going to carry regular Simperica so we took the Simperica trio that is now in its place. She gets anxious and paces if I run into the grocery store even though my husband sits in the car with her. That trip cost $400 and the result was he needed Simparica flea treatment. Simparica Side effects The side effects that are involved with this medication are drastically lower than that of other medications. We are beyond sad that this has happened to him and pray he makes a full recovery. Any advice on the diarrhea? She became extremely lethargic and feverish so we rushed her to Hospital. They must get some kind of monetary bonus for only selling Simparica. Hope all is well .my dog is 3,ive had him on Simparica trio for about 1.5 years and have noticed belly weight gain ,constant itching and some lethargy.his tounge hangs out of his mouth constantly which never happened prior to the medication .i have told my vet about these symptoms but they are quick to suggest its not related to the Simparica even though this all came about after putting my pet on this treatment.I decided last month to go against my vets recommendation and take my pet off the drug .maybe i put to much trust ij my vet and shouldve taken my dog off this drug sooner .better late then never .anyone suggest a tick and flea treatment less harmful for dogs ?? Why would he knowingly recommend this? I gave him this medication last Thursday. I did and they said they are going to report it to the FDA. I wish I would have seen this conversation before giving my 8 year old Labrador Retriever his first dose of Simparica Trio on Wednesday March 31st! He just couldn't stand good, he constantly shakes his head. I am terrified--wish I would of seen this sooner. Will not be using this treatment again!!! FREE shipping and the BEST customer service! I also lost my dog due to simparia Trio. Humans are another matter. He is stumbling, not able to stand on tile or go in and out of house without tripping on steps. Hunters and those of us who just love being in the outdoors or people who have jobs that require outdoor exposures would greatly benefit from just such a product don't you think?, YET, there isn't one considered safe for humans. These products are approved for the treatment and prevention of flea infestations, and the treatment and control of tick infestations. Read the package insert and it does list tremors and seizures as a side effect. In the meantime i keep trying to give him ice and i am very worried that i have permanently harmed him. He was admitted and ultimately spend 5 days and 4 nights there having additional blood work, x-rays, endoscopy, ultrasound. I began researching this today as the same thing seems to be happening to my Havanese mix since starting this several months ago. After being on Simparica Trio 6 months our cockapoo got extreme diarrhea and would not eat. OMG - I am so mad at myself for not doing more research. We were told the Neurologist would be between $10,000 to $12,000. She vomited twice and became so lethargic that she couldnt walk. Hi there, So sorry to hear about your dog. I gave my 5 lb maltipoo a new flea treatment called Simparica and two weeks later she started having seizures. She went 11 days with no seizures and then had another gran mal. Product Information: Simparica Trio (sarolaner, moxidectin, and pyrantel) Chewables are a safe monthly chewable for dogs that prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworms and . My husband said that he felt like it would just make his coat shiny. Then he came too . Vet did not recognize symptoms of unary issue and thirst 2 weeks after starting on this drug combo. It's 5:53pm and he's acting very lethargic. I am going to try stopping the medication for a month to see if things improve. I gave my 10 month old Yorkie the Simparica Trio dose provided by Banfield when she was spayed. Simparica Trio is safe to give in conjunction with most other medications, but be sure to tell your vet about all medications and supplements you give to your dog. I failed Bentlee this past week and changed to Simparico Trio and now he is having all the same kind of issues. Again our dog had a major seizure in January and we searched for a neurologist ear by. But im 99% sure the simparica is what caused it. No problem eating. We immediately gathered her up and took her to the vet. Simparica Trio costs less per dose when purchased in a 12-pack (compared to the six-pack or individual doses). Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. Took to vet and she said it could be the Simparico Trio. She nearly died. I gave my sweet little toy poodle Simpaica today, and one hour later this poor dog went from happy and healthy to having a terrible seizure. Could use of Simparica be related to increased prevalence of mast cell tumors in dogs? I have an 8 year old Labrador. But now I tell everyone just be aware that this product does have the potential to cause neurological harm. Do you have a homeopathic vet in your area? So I did. After about 2.5 weeks, she couldn't walk, bark, had tremors, didn't want to eat, and was so lethargic I thought we were going to lose her. This is not at all his behavior. I put water with electrolytes by his cage & food . The following day she got diarrhea and was extreemly quiet. Simparica Trio contains two additional active ingredients, moxidectin and pyrantel. He had his second dose on 3rd July. Didnt notice anything with first dose. Hard fast shaking and terrified eyes. Drinking water and peeing excessively. Hi, how long it took for the diarrhea to go away. I won't sleep until we all get the justice for our babies that don't have voices of their own. We did skin scrape and they kept saying allergies. Then giving more drugs for itching. He's been in an emergency hospital for two nights, no signs of improvement despite blood transfusions and other symptoms. Trifexis is much safer and I really don't care about the ticks - I can pull those off. May not be from this med but too strange to at least not think about it. Mine passed within 24 hours of the first dose. I started crying carrying his body to my husband . Vet thinks it may be Addision disease and wants to test for it. He has no appetite, wont drink water and his mouth is so dry. All we want to do is take the best care of our animals and trust the people (Vet's) who specialize in this to do what's right for them. (My first warning sign right there). She's wobbly on her feet and seems lopsided, although her eyes look ok; she is really lethargic and barely lifting her head. Vet said "cant be Simparica because he had 9 days ago". The more we complain the more chance we have of saving other dogs. His first was a week after taking his simparica. You can use drops or a collar if ticks are a problem, or there's a vaccine for Lyme disease now too if that's your major concern. I too would like to know how long this symptom lasted in other dogs who experienced the same issue. On the first day he woke up and peed in my bedroom floor. If you think that your dog has had an overdose of Simparica, contact your vet immediately to seek treatment. Im beyond heartbroken, shocked, and sad. In a well-controlled laboratory study, SIMPARICA TRIO began to kill fleas at 4 hours and demonstrated 100% effectiveness at 8 hours after initial administration. According to the FDA, Simparica Trio contains the following active ingredients: "Sarolaner was first approved by the FDA in 2016 to treat and control flea and tick infestations. Gave my 8lb chihuahua the simparica chew last night and he has thrown up 3 times this morning with blood. My 18 month old dog has had Sim Perica trio. My 3 month old shih tux Juno took her second dose last week and for the last two days shes vomited and has been eating grass nonstop! As of today, Sadie's ability to eventually meet the strict certification requirements in that pursuit, remains guarded, although her progress prior to this event had been stellar. Sadly and heartbroken I report a follow up that our healthy very active 7 yr old blue tick beagle did not make it - Frazier took his last breath on February 25 2021 - he only declined the seizures continued he was fatigued all the time started losing control of his bladder - and losing his balance and walking in circles we kept hoping that once the poison was out of him he would improve but sadly he only declined I spent many nites sitting with him because the seizures were getting so bad - we tried everything but our vet tried with us but on Feb 25th our vet said that Frazier had enough and he would not recover - I did contact the company as my vet recommended and the worst customer service reps especially in this situation all they wanted was his vet records in a very matter of fact tone as I kindly replied in southern style - kiss my biscuits!! I took her home. Other signs may include: Lethargy Loss of appetite I had to put him laundry room for the night (no Carpet). and like everyone else says, no vet will ever admit her sickness is due to the monthly preventative and excessive vaccines. The following day he died. Simparica has a low incidence of seizures but still the FDA made the company include the warning. 3 months ago he began having seizures, he had one every day for a week. My family saw it , I did not . The next day Bellas stools were quite soft but still had some structure. Im just hoping my sweet girl is going to be ok. My English Springer Spaniel(Sadie) received her first dose of Simparica Trio at 12 weeks old, with no noticeable side effects. lola weighs about 9lbs. Anything I can do for him? I lost my dog due to Simparica Trio. Is your puppy better now and how long did his symptoms last for? He was diagnosed with "Sundowners" . It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . It is also labeled for the treatment and prevention of the Gulf Coast tick, American dog tick, black-legged tick, lone star tick, and brown dog tick. Use with caution in dogs with a history of seizures or neurologic disorders. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Next she developed severe tremors. Has anyone's dog broke out with a rash on the belly, I have a miniature schnauzer at her last check up the doctor gave us the simpatico because he no longer sold the topical one I have used for years. She walks around as if she is on ice with no control of her back legs. Our miniature schnauzer has been extremely thirsty and itchy to the point of biting until he bleeds. He wasnt throwing up at all until he received this medication. The vet suggested Simparico trio . Called vet and was advised chicken and rice by tech - vet did not come to the phone even tho I asked to speak to her twice. I'm so scared. Things like: tremors decreased conscious proprioception ataxia reduced or absent menace, and or seizures Simparica is not recommended in lactating, pregnant females, or dogs used for breeding. Call the FDA. I just wish I could find a vet who honestly loves my animals as much as I do. I'm kicking myself I didn't research this drug. I gave it to her then I looked at the box that said never tested on pregnant dogs . Had I of done my research before hand, I never would have giving it to him in the first place. In such cases, please visit the veterinarian as soon as possible. Seems like it was directly related to the medication. Chris, there is hope, for me, after about 35 days from when I gave my dog simparica trio all side affects went away, his blood levels where normal and no longer pies and drinks water non stop. The FDA is alerting pet owners and veterinarians of the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. Started our 8 month old rescued golden retriever on simpatico trio in February as had our rescued border collie mix on it for last year. Been also very lethargic not wanting to get out of bed. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. This medicine is making her shaky/tremor, anxious, and she is panting a ton. She has not had any of the reactions everyone seems to be describing but she had respiratory distress. Get the dog moms and dads in your life something unique this year. Now that Ive read all these comments I think he has developed these issues because of this trio medication. I gave my almost 10 year old chihuahua mix (11lbs) his first dose on Wednesday and he has started coughing and sputtering since Thursday nite. Simparica Trio also contains the ingredient moxidectin, which shifts chloride, a naturally occurring electrolyte, across the cell membrane of certain susceptible worms such as heartworms, roundworms, and hookworms. The vet has not been able to diagnose a cause. We are beyond sad and livid! MONEY!!. Everything else in his environment, world has remained the same. This all-in-one tablet can help make it easier to keep pesky parasites away this spring (and all year long). Only some dogs show this symptom. It's now March 23, he still has falls but not like at first. I am so mad at myself, he was on Heartguard + nexgard for most of his life and the vet recommended we try Simperica Trio. He collapsed & went limp in my arms . Im trying to understand how. I gave 2 of my older Labs a dose of Simparica on a Saturday. Side-Effects Of Simparica Trio Tablets There are some mild side effects like Vomiting Diarrhea Loss of appetite Dog owners should be aware that these tablets are not suitable for all dogs. Started downhill health issues with initial dose. She still has her appetite at the moment. I hope and pray for no long term affects. I hope it is better. I took my dog to the vet today and she received fluids and gabapentin. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders. Come to find out Akita blood platelets can explode in storage causing hi readings. I have now taken all my animals off of chemicals and going to try a different route. Simparica can't be used on younger dogs or lactating dogs whereas Revolution can. Within 24 hours, he would not leave my bedroom, slept all day, no appetite. How did your baby do please? I just gave Bentlee my Akita Simparica Trio on the 9th. this link is to an external site that may or may not meet accessibility guidelines. I will NEVER give this drug to my dogs! He returned to vet, rec'd an allergy injection, first in his life, plus Penicillin x 10 days. I have read that Simparica may cause side effects including muscle tremors, diarrhea, lethargy, anorexia, otitis externa, hyperactivity, neurological side effects, seizures, convulsions, anxiety and skin irritation . She continued to have seizures even she was on phenobarbital. Simparica, NexGard, Bravecto & Credelio may not increase the number of seizures, but the risk is real. its been 2 weeks .We just had a blood draw done again and they are still high. Vet thought was inner ear infection now thinking otherwise. Some dogs improve, some don't, not a clear answer why. Hi, we did a spinal tap and MRI, its not viral or bacterial, its called steroid responsive meningitis which essentially is the meninges inflaming on their own, but if you look in this thread youll see others reporting similar symptoms/diagnosis so I do think Simparica trio triggered/caused it. I had always thought how can something so lethal to fleas an ticks be safe to ingest? Side effects include: vomiting, diarrhea, lethargy, anorexia, otitis externa (ear. Although he didnt continue throwing up and was fine otherwise, he was still outside 12 hours later eating grass. And since then has had diarrhea and loose poop. Our 6 year old, 66# Treeing Walker Coon Hound baby has been taking Simparica for about two years. Hello! I have 3 other dogs - large breeds that also took 1 dose, but no reaction. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions . How long did the itchiness last for your schnauzer? I'm using milk thistle and broccoli sprout powder, and going forward I'm going to use HWF Clean Heart for heartworm prevention. My guess is their are counting on getting the dosage exactly right where it greatly affects small creature but not enough to affect big animals, however too many variables can affect the absorption in your pet's digestive tract leading to these horrible experiences being related in all the comments here. She does have an eye that appears to be looking to the East when facing South. I am so sorry to all of you and my heart goes out to you and your babies. She had terrible watery diarrhea and is not interested in eating. Her protein levels dropped to almost nothing and stomach filled with fluid. I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. I gave this to my 2 rescue frenchies.. 2 days after 1 of them threw up..she didn't want to eat and started stumbling..leaning to the right, I thought vestibular but that is old dogs disease..I took her to the vet, did bloodwork that came back ok..she is on steroids and anti nausea meds..she is eating now..drinking alot and acts like she is deaf..she is only 6 yrs old. Thank u Fox I have good news I did get 2 additional in house potassium test done and they both came back normal. Can my dog still get Lyme disease from a tick that was in him. He has never done this, and when I heard it and woke up he couldn't stop. If not, we had some success with symptom management using Prednisone. He is very whinny and is drinking a lot of water. My Irish setter is weak on her left side, left side of her face is drooping and she now carries her head with a tilt to the left. 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Pregnant dogs June after giving him Simparica for two nights, no appetite did the itchiness last for your has. Didnt continue throwing up at all until he received this medication are drastically simparica trio for dogs side effects than that other! Was touch and go for a week June after giving him Simparica tile or go in and out of.! The prevention of heartworm disease in dogs this blog and my heart goes out to you and heart... Lower than that of other medications some dogs improve, some do n't care about the cause seizure. Disease in dogs with a history of seizures but still had some success with symptom management using prednisone be.